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Natural Medicine Journal

August 5, 2020

Tuberculosis Mortality Impacted by Residential Tree Density

An observational study on green spaces and TB patient outcomes

Kurt Beil

ND, LAc, MPH
For TB patients, the greener the neighborhood, the lower the mortality risk. This inverse relationship may hold true for other respiratory conditions as well.

Reference

Blount RJ, Pascopella L, Barry P, et al. Residential urban tree canopy is associated with decreased mortality during tuberculosis treatment in California. Sci Total Environ. 2020;711:134580.

Study Objective

To determine the association between urban tree cover and mortality from community-acquired tuberculosis (TB) infection.

Participants

All patients with diagnosed TB infection in the state of California between the years 2000 to 2012 (N=33,962; median age 46.9 years; 59.4% male), according to the California TB registry.

Design

The researchers tracked participants’ morbidity and mortality status and compared it to the amount of tree cover surrounding their residential address (or, in the case of homelessness, the shelter or street intersection closest to where they spend the majority of their time), as determined by a statewide satellite-based vegetation-survey database. The researchers used 4 different buffer zones of varying radii (50 m, 100 m, 200 m, and 300 m), with tree cover presented as a percentage of total land area, divided into quintiles for analysis.

Data were controlled for demographic, socioeconomic, and clinical covariates: age, sex, race, ethnicity, immigration within 1 year, household income, employment status, substance abuse, homelessness, and concurrent HIV infection.

Outcome Measures

Researchers assessed 2 outcome measures:

  • Mortality rate, subdivided into 3 categories: TB-related, cardio-pulmonary, and other)
  • Acid-fast Bacilli (AFB) sputum smear: the common method for determining the presence of pathogenic TB bacteria

Key Findings

There was an inverse relationship between percentage of tree cover and all-cause, TB-related, and cardio-pulmonary mortality for each of the 4 buffer radii (50 m–300 m). After adjustments for all covariates, comparison of highest to lowest tree cover quintiles demonstrated significant reductions in all-cause mortality risk as follows:

  • 50-m buffer: 22% reduced risk (HR 0.78, 95% CI 0.68–0.90, P=0.0003)
  • 100-m buffer: 21% reduced risk (HR 0.79, 95% CI 0.68–0.91, P=0.002)
  • 200-m buffer: 13% reduced risk (HR 0.87, 95% CI 0.75–1.00, P=0.02)
  • 300-m buffer: 11% reduced risk (HR 0.89, 95% CI 0.77–1.04, P=0.03)

In addition, the researchers measured an inverse relationship between percentage tree cover and AFB sputum smear positivity for each of the 4 buffer radii. After adjustments for all covariates, comparison of highest to lowest tree cover quintiles demonstrated significant reductions in AFB sputum smear positivity as follows:

  • 50-m buffer: 7% reduced odds (OR 0.93, 95% CI 0.86–1.01, P=0.02)
  • 100-m buffer: 11% reduced odds (OR 0.89, 95% CI 0.82–0.96, P=0.001)
  • 200-m buffer: 14% reduced odds (OR 0.86, 95% CI 0.79–0.93, P=0.0002)
  • 300-m buffer: 12% reduced risk (OR 0.88, 95% CI 0.81–0.96, P=0.002)

AFB sputum smear positivity was directly associated with patient mortality, as is typical for TB infection.

Commentary

This current study is the first to investigate the effects of green space on a specific respiratory-based infectious disease (TB). Readers of the “green space and health” literature are aware that residential proximity to various forms of “nature” has a positive impact on health status and disease prevalence.1 Large-scale public-health surveys have shown the inverse association between living in proximity to green space and mortality rates.2,3 Specifically, a recent study from China has demonstrated that rates of respiratory-based mortality decline when people live surrounded by greater density of greenery.4

This is a timely finding for potentially addressing the current global COVID-19 pandemic, which has also shown an association between air pollution concentration and respiratory morbidity and mortality.

There are many mechanisms that account for nature’s health-promoting ability, which have been discussed in this and other journals.5,6 One of the most relevant related to respiratory-disease mortality is vegetation’s ability to reduce air pollution and improve air quality. This occurs via 2 processes:

  1. The deposition of particulate matter (PM), such as soot, ash, and combustion products, on vegetative surfaces, straining them from the air; and
  2. The absorption of toxic gases (eg, NOx, O3) into leaves as part of plants’ respiratory function, filtering them from the air.

The magnitude of vegetation-based improvement in air quality and reduction in airborne pollutants is substantial, with 1 estimate calculating around 18 million tons of airborne pollutants removed by trees in the United States annually.7 This benefits human health in multiple ways including a reduction in pathogenic air toxins as well as removal of immuno-suppressive pollutants that facilitate respiratory disease. These and other benefits (eg, reductions in air temperature as well as psychophysiological stress and allostatic load8,9) have been calculated to prevent 670,000 cases of acute respiratory disease annually, with an assessed healthcare value of $6.8 billion saved.10 It is likely the current study’s focus on TB mortality in California is just 1 of multiple specific conditions benefitted by greenery-based air-quality improvements.

Other respiratory conditions may similarly benefit from proximity to green spaces’ air-quality improvements. This is a timely finding for potentially addressing the current global COVID-19 pandemic, which has also shown an association between air pollution concentration and respiratory morbidity and mortality.11,12 Reductions in ambient air pollution via vegetative deposition and filtration could assist in decreasing coronavirus cases and deaths. This strategy may be especially effective in addressing issues of environmental injustice and inequality among communities of the urban poor and communities of color disproportionally affected by COVID-19, air-quality issues, and lack of healthy green spaces.13,14

Limitations

This was an observational study, and therefore, causality of tree density on TB mortality cannot be established. In addition, the researchers assessed tree density only around patients’ residential address, not other locations such as work or school where participants may also have encountered green space effects. However, the findings of this study in conjunction with other research lend credibility to the existence of a strong and statistically significant inverse relationship.

Conclusion

Multiple factors influence the progression of an infectious disease like TB. External factors such as air pollution are well-known to modulate respiratory-disease severity. Environmental features, including the density of air quality–improving trees surrounding an individual’s residence, have the potential to significantly affect health status and mortality rates throughout the population, particularly for at-risk groups in underserved communities.

Categorized Under

Kurt Beil

ND, LAc, MPH

Kurt Beil, ND, LAc, MPH, is a naturopathic physician and licensed acupuncturist and holds a master’s degree in public health focused on the benefits of green space as a sustainable public-health promotion tool. He did his postdoctoral work at the Helfgott Research Institute on biomarker and psychometric assessment of the restorative and therapeutic effects of natural vs built urban environments. Dr Beil has been an advisor to the Children & Nature Network’s “Nature Research Database” and was the founding cochair of the Nature & Health subcommittee of the Intertwine Alliance in Portland. He also moderates a Facebook group NDs for Nature for the naturopathic medicine community on the clinical health benefits of contact with nature. Dr Beil maintains a clinical naturopathic and Chinese medicine practice in Happy Valley, Oregon, focusing on chronic disease. He can be reached via email or www.drkurtbeil.com.

References

  1. Twohig-Bennett C, Jones A. The health benefits of the great outdoors: a systematic review and meta-analysis of greenspace exposure and health outcomes. Environ Res. 2018;166:628-637.
  2. Rojas-Rueda D, Nieuwenhuijsen MJ, Gascon M, Perez-Leon D, Mudu P. Green spaces and mortality: a systematic review and meta-analysis of cohort studies. Lancet Planet Heal. 2019;3(11):e469-e477.
  3. Mitchell RJ, Popham F. Effect of exposure to natural environment on health inequalities: an observational population study. Lancet. 2008;372(9650):1655-1660.
  4. Ji JS, Zhu A, Lv Y, Shi X. Interaction between residential greenness and air pollution mortality using the Chinese Longitudinal Healthy Longevity Survey: a longitudinal analysis. Lancet Planet Heal. 2020;4:e107-e115.
  5. Beil K. Search results [for the word “Beil” for Natural Medicine Journal articles on greenspace and health]. Natural Medicine Journal. https://www.naturalmedicinejournal.com/search/author/beil. Accessed July 10, 2020.
  6. Kuo FEM. How might contact with nature promote human health? Promising mechanisms and a possible central pathway. Front Psychol. 2015;6:1093.
  7. Nowak DJ, Crane DE, Stevens JC. Air pollution removal by urban trees and shrubs in the United States. Urban For Urban Green. 2006;4(3-4):115-123.
  8. Nowak D, Heisler GM. Air quality effects of urban trees and parks. Natl Recreat Park Assoc Res Ser. 2010.
  9. Egorov AI, Griffin SM, Converse RR, et al. Vegetated land cover near residence is associated with reduced allostatic load and improved biomarkers of neuroendocrine, metabolic and immune functions. Environ Res. 2017;158:508-521.
  10. Nowak DJ, Hirabayashi S, Greenfield E. Tree and forest effects on air quality and human health in the United States. Environ Pollut. 2014;193:119-129.
  11. Wu X, Nethery R, Sabath MB, Braun D, Dominici F. Exposure to air pollution and COVID-19 mortality in the United States: A nationwide cross-sectional study. medRxiv. 2020. doi:10.1101/2020.04.05.20054502
  12. Zhu Y, Xie J, Huang F, Cao L. Association between short-term exposure to air pollution and COVID-19 infection: Evidence from China. Sci Total Environ. 2020;727:138704.
  13. Brandt EB, Beck AF, Mersha TB. Air pollution, racial disparities, and COVID-19 mortality. J Allergy Clin Immunol. 2020;146(1):61-63.
  14. Park Y, Guldmann JM. Understanding disparities in community green accessibility under alternative green measures: a metropolitan-wide analysis of Columbus, Ohio, and Atlanta, Georgia. Landsc Urban Plan. 2020;200:103806.

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